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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-634 |
| Subject |
Honokiol ether derivatives for Butrylcholinesterase Inhibitor |
| Authors |
Cheolmin Jeon*, haneul lee, YUJUNG KANG, jeongeun song, jintaek Oh, Jeong Ho Park1,*
Department of Chemical & Biological Engineering, Hanbat National University, Korea
1Division of Applied Chemistry & Biological Enginee, Hanbat National University, Korea
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| Abstract |
We have been trying to find out new drug candidate compounds for Alzheimer's drugs based on the cholinergic theory. Honokiol is one of the major active component of the genus Magnolia having antitumorigenic, neurotrophic, antithrombotic, anti-inflammatory, antioxidant, and antiviral activity, etc. Honokiol ether derivatives were synthesized by the Wiliamson ether synthesis reaction between honokiol and alpha-halo esters or amides. In vitro cholinesterase [acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE)] inhibitory activities were evaluated by using Honokiol ether derivatives. The IC50 value of compound 1 is 0.11±0.34μM which is more effective IC50 value than galantamine (IC50 = 9.4±2.5μM againstBuChE). |
| E-mail |
cjfals2970@naver.com |
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121st General Meeting of the KCS