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| Type |
Poster Presentation |
| Area |
Physical Chemistry |
| Room No. |
Event Hall |
| Time |
4월 20일 (금요일) 11:00~12:30 |
| Code |
PHYS.P-199 |
| Subject |
Cancer Biomarker Sensor based on Three-Dimensional Carbon Nanotubes network structure in the Microfluidic Platform |
| Authors |
Su Jin Park, Fadilatul Jannah1, Haiwon Lee*
Department of Chemistry, Hanyang University, Korea
1Chemistry, Hanyang University, Korea
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| Abstract |
A hierarchical carbon nanotubes three-dimensional network structure (3DN-CNTs) has been introduced as an effective system for biomarker recognition in the microfluidic platform.(1) Quantification of the biomarker was performed using fluorescence-based immunoassay. The capturing efficiency of the biomarker was enhanced because of the high surface area of the 3DN-CNTs system. As point-of-care-diagnostic system, this platform has high sensitivity, small sample volume requirement, and short detection time compared to the static system. Microfluidic system can be a platform for detection of cancer biomarkers in a short time due to local topographic interaction with the analytes. As a result, this platform has similar limit of the detection with commercialized immunoassay method (1 ng/ml) while the sample volume requirement and detection time was decreased dramatically. The detection time of cancer biomarker CA125 in fluidic system was decreased approximately one-third (38 minutes) compared to the static system which is applicable for point-of-care-diagnostics system. Our microfluidic platform can be used to facilitate sensitive and specific detection of cancer biomarker in the biological and clinical fields.
References
1. J. E. Seo, T. J. Lee, S. B. Ko, H. G. Yeo, S. H. Kim, T. Y. Noh, S. M. Song, M. M. Sung and H. W. Lee, “Hierarchical and Multifunctional Three-dimensional Network of Carbon Nanotubes for Microfluidic Applications”, Adv. Materials., Vol. 24, No. 15, pp. 1975-1979, 2012
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| E-mail |
sjp2453@naver.com |
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121st General Meeting of the KCS