121st General Meeting of the KCS

Type Poster Presentation
Area Electrochemistry
Room No. Event Hall
Time 4월 20일 (금요일) 11:00~12:30
Code ELEC.P-620
Subject A glucose biosensor using osmium mediator–tethered poly(vinylimidazole) (PVI-Os) for continuous glucose monitoring
Authors Min Heo, Hee June Jeong, Seonhwa Lee1, Jae Ho Shin2,*
Medical Sensor·Biomaterial Research Institute, Kwangwoon University, Korea
1Department of Chemistry, Kwangwoon University, Korea
2Medical Sensor·Biomaterial Research Institute / Department of Chemistry, Kwangwoon University, Korea
Abstract Diabetes mellitus is a group of metabolic diseases which has high blood sugar levels over a prolonged period. If left untreated, diabetes can cause many complications such as heart disease, stroke, chronic kidney failure, diabetic ketoacidosis, or death. The blood glucose levels of patients with diabetes mellitus should be tightly monitored. In general, diabetic patients have used the strip-type glucose sensors. Because such strip-type sensors provide the instantaneous value, patients cannot immediately respond to hyperglycemic or hypoglycemic events. On the other hand, in vivo glucose biosensors can determine the glucose levels in real-time, allowing to effectively warn hyperglycemic or hypoglycemic conditions. Most glucose biosensors for continuous glucose monitoring (CGM) are based on the first generation glucose biosensors. Unfortunately, the first generation glucose biosensors which require higher oxidation potential (0.6 ~ 0.8 V vs. Ag/AgCl), have been interfered by electroactive species such as ascorbic acid, uric acid, and acetaminophen. To reduce the interfering effect, the second generation glucose biosensors with electron mediators which have relatively lower oxidation potential (0 ~ 0.2 V) are suggested. Although the second generation glucose biosensors are useful to reduce the interfering effect, the application of the second generation glucose biosensors have been limited for continuous glucose monitoring because the electron mediators have potential toxicity when it is leached out to human body. Herein, a glucose biosensor is fabricated by using osmium mediator–tethered poly(vinylimidazole) (PVI-Os), and evaluated in terms of the glucose response, interfering effect, and lifetime.
E-mail uncompress@kw.ac.kr