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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-636 |
| Subject |
Characteristics of Drug Delivery Contact Lens with Monomer and Tear pH |
| Authors |
Guen hei Kim, Hyeran Noh1,*
Convergence Institute of Biomedical Eng. & Bio., Seoul National University of Science & Technology, Korea
1Department of Optometry, Seoul National University of Science & Technology, Korea
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| Abstract |
We developed soft contact lens for drug delivery on physiological tear pH range of 5.8 ~ 8.35. In this study, HEMA (hydroxyethyl methacrylate) - based drug contact lenses were prepared and their drug release with monomer (-VP (vinylpyrrolidone), -NIPAAm (N-isopropylacrylamide), -TRIM (3-(trimethoxysilyl)propyl methacrylate)) and tear pH were investigated. Drug contact lenses were immersed in buffer (pH 5.80 ~ 8.03) and released drug amount were analyzed, using UV spectrophotometer. As a result, at weak basicity (pH 8.03), the cumulative release of HPMC from contact lens (p-HEMA-VP) were increased. On the other hand, contact lenses polymerized with NIPAAm or TRIM released less drug amount. With change of functional monomers, concentration, such as -VP, -NIPAAm, were controlled, the hydrogel lens were swelled or de-dwelled due to electric repulsive or attractive forces between ions in tear solutions and the monomers. Anionic hydrogels in acidic solution was observed to be shrunken due to the electric attractive forces within the hydrogel network; the opposite phenomenon appears when the solution is basic. In conclusion, anionic or cationic polymer based contact lens can be utilize as selective drug-releasing media considering tear pH depending on ophthalmic diseases. |
| E-mail |
hexa10@hanmail.net |
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121st General Meeting of the KCS