Transition metal catalyzed synthetic methods of heterocyclic compounds such as furan, pyrrole, isoquinolines, pyridines, and isoindoles are current interests in organic chemistry. Nitrone derivatives represents an useful synthetic intermediates in natural product. Nitrones can undergo several reactions such as 1,3-dipolar cycloadditions, nucleophilic addition reactions, and radical trapping reaction. Recently we described a one-pot method for the synthesis of isoindoles containing a quaternary carbon center under microwave irradiation catalyzed by Rh(III) and Cu(II). In this research, we describe rhodium(III)-catalyzed one-pot synthesis of nitrone derivatives which have quaternary carbon center from oximes and electron-withdrawing group-substituted alkenes in the presence of Cu(OAc)2 . H2O. |