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| Type |
Poster Presentation |
| Area |
Analytical Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
ANAL.P-281 |
| Subject |
Anti-inflammatory activity of streptazolin purified from a novel strain of Streptomyces sp. MJM12405 |
| Authors |
chun whan choi
Biocenter, Gyeonggido Business and Science Accelerator, Korea |
| Abstract |
Streptazolin, an alkaloid, was isolated from a soil-born actinomycete, Streptomyces sp. MJM12405 which was collected in the Gyeonggi-do province of Korea. The structure of this compound was determined by the 1D, 2D NMR and HRMS analyses. Anti-inflammatory effect of streptazolin was evaluated with RAW 264.7 cells. The ethyl acetate (EtOAc) extract of the Streptomyces sp. MJM12405 was found to show significant anti-inflammatory activity with the lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Cell viability was determined using an MTT assay after treated with various concentrations of the isolated constituent. Inhibition rates of NO production induced by LPS was measured by reaction using Griess reagent. This is the first report of anti-inflammatory activity of the purified streptazolin compound from actinomycete. |
| E-mail |
cwchoi78@gmail.com |
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121st General Meeting of the KCS