Pyrazoles are among the most significant heteroaromatic compounds widely found in biologically and pharmacologically active molecules. They exhibit a variety of biological properties including anti-inflammatory, antibacterial, analgesic, antifungal, antipyretic, antiviral, anticancer, antidiabetic, antiobesity, and plant growth regulating activities, as well as protein kinase, Cox-2, and HIV-1 reverse transcriptase inhibitory functions. They have been used as valuable building blocks and structural motifs in the synthesis of natural products, agrochemicals, dyes, and medicines. Moreover, pyrazoles are employed as ligands, cosmetic colorings, and UV stabilizers. To date, a number of substituted N-arylpyrazoles including difenamizole, celebrex, rimonabant, and fipronil have been commercialized as pharmaceuticals and insecticides. Typical approaches towards the synthesis of pyrazoles are based on the reaction of hydrazines with 1,3-dicarbonyl compounds or unsaturated hydrocarbons by condensation and oxidation sequence, the reaction of aryl amines with 1, 3-dicarbonyl compounds forming β-amino α,β-enoates or enones, which would react further with nitriles. Accordingly, there is a demand for a facile one-step approach for the synthesis of pyrazoles. Herein, we present synthesis of polysubstituted N-arylpyrazoles by oxidative [2+2+1] cycloaddition of readily available arylhydrazine hydrochlorides with β-enamino esters by using indium (III) catalyst (Scheme 1). This protocol proceeds via Michael-type addition followed by the elimination reaction, and aerobic oxidation in the presence of a silver catalyst leading to the final product.