121st General Meeting of the KCS

Type Poster Presentation
Area Life Chemistry
Room No. Event Hall
Time 4월 20일 (금요일) 11:00~12:30
Code BIO.P-294
Subject Artificial skin film using hydrophobic silica nanocatalyst
Authors Do Hyun Bae, Yong Ho Kim1,*
GlobalBioMedicalengineering, Sungkyunkwan University, Korea
1Department of Chemistry, SKKU Advanced Institute o, Sungkyunkwan University, Korea
Abstract Artificial skin has primarily been used as a biomaterial to regenerate damaged skin tissues of patients by burns or skin disorders. Recently, according to one paper that is published at MIT where they succeeded in reproducing youthful skin by using cross-linked polymer through reaction of hydrosilylation by platinum catalyst. This artificial skin film has excellent effect on wrinkle improvement, even though it shows a problem with its toxicity and stability by using platinum catalyst. We researched a solution for this problem, a platinum catalyst was adsorbed on polydimethylsiloxane (PDMS) coated silica nanoparticles. First, the hydrophobical coated silica nanoparticles in ethanol solvent are washed and dispersed. Then, the platinum catalyst is sufficiently dispersed in the same solvent. Hydrophobic interaction with the silica nanoparticles and catalyst is performed using a sonicator. The catalyst adsorbed nanoparticles are dried at room temperature. silicon based emulsion and reaction emulsion except karstedt's catalyst are prepared for skin film formation test. The silica nanocatalyst were mixed with reaction emulsion. To form the artificial skin film, silicon based emulsion is spread and then particle mixed reaction emulsion was applied on it. As a result, the formation time of the artificial skin film using the catalytic silica nanoparticles was slightly slower than made only with the karstedt's catalyst, but there was no significant difference in the physical properties. These catalytic nanoparticles have possibility to improve the stability caused by Karstedt’s catalyst aggregation and the problem of toxicity that platinum catalyst can penetrate directly into cells. So this nanocatalyst may apply to a variety of field such as cosmetics and pharmaceutical products.
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