|
|
| Type |
Poster Presentation |
| Area |
Life Chemistry |
| Room No. |
Event Hall |
| Time |
4월 20일 (금요일) 11:00~12:30 |
| Code |
BIO.P-296 |
| Subject |
Rational design of self-assembling peptide for conductive, non-biodegradable hydrogel
|
| Authors |
Jiyoung Nam, Yong Ho Kim1,*
SKKU Advanced Institution of Nano Technology, Sungkyunkwan University, Korea
1Department of Chemistry, SKKU Advanced Institute o, Korea
|
| Abstract |
Self-assembling biomolecules have great advantages for developing a new material in terms of controlling assembly structure with tailored, high-level functions. Extensive researches have shown that advanced functional biomaterials can be developed by rationally designing the secondary structure of self-assembling peptide, but unwanted proteolytic degradation of peptide-based material imposes challenges on chronic in vivo utilization. To address the limitation, our focus was on peptidomimetic foldamer, particularly a β-peptide because it has not only the ability to mimic the structural and chemical characteristics of natural peptides, but excellent structural and proteolytic stability. We envisaged that the controlled complexation of self-assembling β-peptide with conductive nanomaterial would provide a biocompatible, conductive biomaterial that can be used to acquire biosignals with minimum tissue damages. Here, we demonstrate a rational design of supramolecular β-peptide-based hydrogel for conductive and non-biodegradable hydrogel. Small-angle X-ray scattering (SAXS) and transmittance electron microscopy (TEM) images revealed the end-to-end assembling of β-peptide hexamers to construct axially-grown nanofibers. Interestingly, β-peptide nanofiber is found to wrap single wall carbon nanotube (CNTs) bundles in a way of superhelical mode. We demonstrated that the conductive hydrogel had a multiscale versatility both as surface electrocorticography (ECoG) electrode and local-field potential (LFP) electrode and collectively augment neural signals. The enzymatically and electrochemically enhanced self-assembling peptides and their nanomaterial complexes hold promising future as a new type of biomaterials for biosensor, tissue engineering, and regenerative medical devices. |
| E-mail |
njy5515@skku.edu |
|
121st General Meeting of the KCS