121st General Meeting of the KCS

Type Poster Presentation
Area Medicinal Chemistry
Room No. Event Hall
Time 4월 19일 (목요일) 11:00~12:30
Code MEDI.P-646
Subject Anti-adhesion barrier made of Pullulan, Carboxymethyl cellulose and Pluronic F127 for prevent postoperative adhesions
Authors jeongman An*, Juhyung Shin1, YuJin Hwang1, Yong-kyu Lee*
Department of Chemical & Biological Engineering, Korea National University of Transportation, Korea
1Chemical & biological eng., Korea National University of Transportation, Korea
Abstract Pullulan has been widely investigated in the biomedical applications due to their diverse physiochemical properties, enhanced biocompatibility and biodegradability and minimized toxicology profiles. In this study, we made antiadhesive solution for postoperative tissue adhesion barrier with stickiness property of pullulan. And, we mixed the CMC to increase the viscosity and also to increase the time that the barrier stays on the wound site where adhesion will occur. Further, we blended Pullulan/CMC with Pluronic F127 (F127) in different ratios from solution to develop thermosensitive injectable hydrogels. Later, we studied the in vitro toxicology profiles of Pullulan/CMC barrier solution and Pullulan/CMC/F127 injectable hydrogels. Further, we studied in vivo therapeutic efficacy Pullulan/CMC barrier solution and Pullulan/CMC/F127 injectable hydrogels. In conclusion, we believe that our product.could prevent the postoperative tissue adhesions with enhanced stability and biocompatibility.
E-mail jumpyoho@naver.com