121st General Meeting of the KCS

Type Poster Presentation
Area Material Chemistry
Room No. Event Hall
Time 4월 20일 (금요일) 11:00~12:30
Code MAT.P-513
Subject In vivo compatibility study on chitosan-hydroxyapatite composite film depending on degree of deacetylation
Authors Ki-Jae Jeong, CAIFENG WANG, Jaebeom Lee1,*
Department of Cogno-Mechatronics Engineering, Pusan National University, Korea
1Optics and Mechatronics Engineering, Pusan National University, Korea
Abstract Chitosan is one of promising polymers for applications in various fields. However, despite diverse research studies conducted on its biocompatibility, its uses are still limited. The main factor that can affect its physical, chemical and biological properties is the degree of deacetylation (DOD), which represents the proportion of deacetylated units in the polymer. In this article, the in vivo biocompatibility of chitosan-hydroxyapatite composite films composed of chitosan with different DOD values was investigated by traditional biological protocols and novel optical spectroscopic analyses. The DOD of the chitosan was estimated and calculated by Raman spectroscopy, Fourier transform infrared spectroscopy, and proton nuclear magnetic resonance spectroscopy. The chitosan with the higher DOD induced a higher incidence of inflammation in skin cells. The amino group density, biodegradability, and crystallinity of chitosan are three possible factors that need to be considered when determining the biocompatibility of the films for in vivo application, since they led to complicated biological results, resulting in either better or worse inflammation even when using chitosan products with the same DOD. This basic study on the relationship between the DOD and inflammation is valuable for the development of further chitosan-based researches.
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