121st General Meeting of the KCS

Type Poster Presentation
Area Polymer Chemistry
Room No. Event Hall
Time 4월 20일 (금요일) 11:00~12:30
Code POLY.P-58
Subject Thermo-responsive Organic-inorganic Nanocomposites for SERS-based Biosensing
Authors Hyunki Kang, Eun Young Hwang1, Dong Woo Lim2,*
Bionano technology, Hanyang University, Korea
1Bionano Technology, Hanyang University, Korea
2Department of Bionano Engineering, Hanyang University, Korea
Abstract Surface-enhanced Raman scattering (SERS) is one of the powerful techniques to detect and identify biomolecules for biosensing and stimuli-responsive SERS nanoprobes have been of great interest for high sensitivity. Herein, we report thermo-responsive organic-inorganic nanocomposites, which were comprised of thermo-responsive di-block copolymer-grafted nanoscale graphene oxide (NGO) using two different approaches of “grafting to” and “grafting from” and gold nanorods (GNRs). The thermo-responsive di-block copolymer, poly(N-isopropylacrylamide-b-acrylic acid), poly(NIPAM-b-AAc), was polymerized by reversible addition-fragmentation chain transfer (RAFT) polymerization. In “grafting to” approach, thiol-functionalized block copolymers were conjugated with maleimide-functionalized NGO as polymer brushes by thiol-Michael addition reaction. On the other hand, the polymer brushes in “grafting from” method were grown from chain transfer agent-functionalized NGO surface by RAFT polymerization. Poly(NIPAM-b-AAc) brushes of the NGO were complexed with GNRs via electrostatic interactions between negatively charged poly(AAc) blocks and positively charged GNRs. The organic-inorganic nanocomposites showed enhanced SERS signal depending on temperature. This work would have great potential in temperature-dependent SERS-based biosensing applications.
E-mail manddang@hanyang.ac.kr