121st General Meeting of the KCS

Type Poster Presentation
Area Organic Chemistry
Room No. Event Hall
Time 4월 19일 (목요일) 11:00~12:30
Code ORGN.P-531
Subject 3D Molecular Architectures with Concave-Faced Cuboid Shape by the Self-Assembly of Chimeric Foldamer of 11- and 14/15-Helix
Authors Jae-Hoon Eom, Rokam Jeong, Jintaek Gong1, Hee-Seung Lee*
Department of Chemistry, Korea Advanced Institute of Science and Technology, Korea
1Natural Science Research Institute, Korea Advanced Institute of Science and Technology, Korea
Abstract Research on self-assembly is a very attractive field as a methodology for mimicking the sophisticated three-dimensional structures of natural system. The design of the building block is very important to understand the formation principle of the complex structure, and foldamers are good candidates due to its simple and rigid secondary structure. Our group recently reported various foldectures which have very uniform and well-defined 3D architectures by the self-assembly of peptide foldamers. However, these foldectures consist of simple homogeneous helices of eleven or twelve type. To better understand the correlation between the helical type and the three-dimensional structure, it is necessary to study the foldamers mixed with various helical types. Herein we report a new foldecture which has a concave-faced cuboid shape by the self-assembly of chimeric foldamer of 11- and 14/15-helix. Foldamer packing motif was revealed by X-ray diffraction method and provides an important structural information to build an unusual 3D architecture. This study will play a important role in designing complex 3D architectures.
E-mail jheom@kaist.ac.kr