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Type |
Poster Presentation |
Area |
Organic Chemistry |
Room No. |
Event Hall |
Time |
4월 19일 (목요일) 11:00~12:30 |
Code |
ORGN.P-532 |
Subject |
Foldectures from the Self-Assembly of Racemic α/β-peptide Foldamers |
Authors |
Jae-Hoon Eom, Rokam Jeong, Jintaek Gong1, Kim Jaewook2, Hee-Seung Lee* Department of Chemistry, Korea Advanced Institute of Science and Technology, Korea 1Natural Science Research Institute, Korea Advanced Institute of Science and Technology, Korea 2chemistry, Korea Advanced Institute of Science and Technology, Korea |
Abstract |
Foldectures are a family of microscale molecular architecture with highly homogeneous and 3D morphologies derived from the self-assembly of peptide foldamers. Foldectures composed of single enantiomer are demonstrated to have well-defined molecular packing structure analyzed by powder X-ray diffraction analysis(PXRD). Self-assembly with racemic peptide building blocks has rarely reported, while the studies on the racemic crystallization are known to be DNA or protein structures. Self-assembly of racemic foldamers give rise to new morphologies and properties. In this study, we used heptameric foldamer composed of α-amino acid (aminoisobutyric acid, Aib) and a cyclic β-amino acid (trans-2-aminocyclopentane carboxylic acid, ACPC) in a α/β peptide foldamer. This hepta-peptide forms a stable 11-helical secondary structure and yields truncated pyramid shape in assembly.
We has recently reported that the self-assembled structure change by ratio and molecular packing structure of an elongated parallelogram plate shaped foldecture composed of a 1:1 racemic mixture of 11-helical peptide foldamers was resolved by PXRD. This researches is fundamental differences between self-assembling enantiopure peptidic material and racemic mixtures and understand the complex structures.
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E-mail |
rokamjeong@kaist.ac.kr |
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