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| Type |
Poster Presentation |
| Area |
Organic Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
ORGN.P-538 |
| Subject |
Hypoxia detecting fluorescent probe using Seoul Fluor`s rational changing of fluorescent property at reducible condition |
| Authors |
Minchul Shin, Eunha Kim1,*
Molecular Science and Technology, Ajou University, Korea
1Department of Molecular Science and Technology, Ajou University, Korea
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| Abstract |
Hypoxia is a condition where oxygen is insufficient. Hypoxia is known for having relation with diseases such as stroke, heart attack, cancer. According to researches relating to tumor, rapid growing of tumor brings decreasing oxygen concentration in tissue and develops hypoxia condition. Therefore, detecting hypoxia condition in cellular level can be important challenge for studying cancer. Fluorescent is chosen for detecting sensor because of several advantages which contain high sensitivity, detection in living cell, high selectivity. In particularly, Seoul Fluor can be efficient fluorophore because Seoul Flour has feature that is changing fluorescent property as substituents are alternated. Herein we rationally design hypoxia detecting Seoul Fluor dye containing nitro group. At less oxygen condition, nitro group is tend to reduced to amine. Nitro group show quenching effect on dye that we design. consequently, this is expected to be “turn-on” in hypoxia condition |
| E-mail |
p20509p@ajou.ac.kr |
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121st General Meeting of the KCS