|
Type |
Poster Presentation |
Area |
Polymer Chemistry |
Room No. |
Event Hall |
Time |
4월 20일 (금요일) 11:00~12:30 |
Code |
POLY.P-61 |
Subject |
Stimuli-responsive Elastin-Resilin Block Copolymers for Injectable Hydrogels |
Authors |
Aamna Basheer, Jae Sang Lee, Min Jeong Kang, Jae Hee Lee, Dong Woo Lim1,* Department of Bionanotechnology, Hanyang University, Korea 1Department of Bionano Engineering, Hanyang University, Korea |
Abstract |
Injectable protein hydrogels with stimuli-responsiveness have attracted great interest in biomedical field because of their noninvasive applications. This work was motivated to design block copolymers of elastin-based polypeptides (EBPs) with thermo-responsivenss and resilin-based polypeptides (RBP) with resilient property for injectable hydrogels. The ABA triblock copolymers, which were composed of thermally responsive EBP end blocks and hydrophilic RBP middle block, were genetically engineered and purified via inverse transition cycling. Below the lower critical solution temperature (LCST) of EBPs, the block copolymers were completely soluble and self-assembled into physically cross-linked hydrogel above it due to thermal aggregation of terminal EBP blocks and hydrated middle block. Oscillation rheological experiments showed a clear crossover point of storage- and loss modulus above LCST. The self-assembled hydrogels showed enhanced mechanical properties at 37 ℃ and showed reversibility with minimal hysteresis as the temperature decreased. These stimuli-responsive polypeptide hydrogels would be promising for biomedical applications. |
E-mail |
aamna@hanyang.ac.kr |
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