121st General Meeting of the KCS

Type Poster Presentation
Area Organic Chemistry
Room No. Event Hall
Time 4월 19일 (목요일) 11:00~12:30
Code ORGN.P-542
Subject Synthesis of Fluorescence Probes as Potential Tau Protein Tracers
Authors Ji Soo Seo, Young Jin Choi1, Ghilsoo Nam2,*
Department of Chemistry, Kyung Hee University, Korea
1Division of Bio-Med, University of Science & Technology, Korea
2Center for Neuro-Medicine, Korea Institute of Science and Technology, Korea
Abstract Alzheimer's Disease (AD) is the most common neurodegenerative brain disorder, but there is no cure or confirmative diagnosing tool for AD. Research has confirmed the presence of two types of lesions in the cerebral cortex. One is amyloid plaques that found at the extracellular level and associated with amyloid beta peptide (Aβ), and the other is neurofibrillary tangles(NFTs), found inside the neurons. While researchers have extensively focused on amyloid plaques to overcome AD, recently human pathological studies have shown that NFTs density is directly correlated with neurodegeneration not Aβ. NFTs comprise bundles of paired helical filaments (PHFs) that result from the abnormal aggregation of hyperphosphorylated tau protein. NFTs have shown a significant correlation with the degree of cognitive impairment, and tau imaging has been reported as a more robust predictor of AD progression. Also optical imaging modalities do not use isotope labeling, making them attractive alternatives to the classical nuclear imaging techniques represented by Positron Eimission Tomography (PET). Thus, nonivasive imaging of tau aggregates has been emphasized as a diagnostic tool for AD. In this study, we tried to design novel probes selectively bind to tau aggregates on the basis of the structure of [18F]AV-1451 and diverse chromophores in order to emit the light in the NIR region. We will discuss detailed their fluorescence intensity and physicochemical properties.
E-mail 117038@kist.re.kr