121st General Meeting of the KCS

Type Oral Presentation
Area Oral Presentations of Young Scholars in Organic Division
Room No. Halla Hall B
Time THU 09:30-:
Code ORGN.O-3
Subject Ni-catalyzed synthesis of 1,5-disubstituted 1,2,3-triazoles
Authors Woogyum Kim, Sung You Hong1,*
Department of Chemical Engineering, Ulsan National Institute of Science and Technology, Korea
1Ulsan National Institute of Science and Technology, Korea
Abstract Regioselective 1,4-disubstituted triazoles have been accessed particularly using copper-catalyze azide-alkyne cycloaddition.[1] In sharp contrast, the synthetic methods to afford 1,5-disubstituted compounds have been developed relatively slowly. Ruthenium- and lanthanide-based catalytic reactions have been practically limited due to the air- and moisture sensitivities. Herein, we unveil nickel-catalyzed highly selective 1,5-disubstituted triazole formation reaction under the ambient conditions.[2] In particular, the reaction protocol is compatible with organic solvent and aqueous solvent conditions, which can be potentially applied to the biochemical approaches. References: [1] M. Meldal, C. W. Tornoe, Chem. Rev. 2008, 108, 2952. [2] W. G. Kim, et al. J. Am. Chem. Soc. 2017, 139, 12121.
E-mail hun12333@naver.com