121st General Meeting of the KCS

Type Poster Presentation
Area Medicinal Chemistry
Room No. Event Hall
Time 4월 19일 (목요일) 11:00~12:30
Code MEDI.P-652
Subject Versatile bioconjugated affibody-glutathione transferase protein gate keeper for drug delivery nanoparticle
Authors Joon Yong Oh, Ho Young Kim1, Sang Hoon Joo2, Chaekyu Kim3,*, Ja-Hyoung Ryu3,*
Department of Chemistry / Department of Chemical E, Ulsan National Institute of Science and Technology, Korea
1School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology, Korea
2Division of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology, Korea
3Department of Chemistry, Ulsan National Institute of Science and Technology, Korea
Abstract Among the drug delivery carriers, mesoporous silica nanoparticles (MSN) have received wide attention due to their tunable pore morphology, high specific surface area, easy surface modification/ bioconjugation for targeting and physiochemical stability. They can host the therapeutic compounds due their void cores, as extra reservoir for drug storage. Also gatekeeper system can maximize the characterization of MSN for being used drug delivery systems. Although there are many kinds of gatekeeper systems ,like polymer, peptide, metal nanoparticles, not much improve in protein gate keeper. Protein gate keeper could be one of the most powerful platform by using direct interaction between receptor protein and affibody. Drug can be loaded into the pores of the carrier at large quantity. Recently, non-covalent protein gatekeepers have received significant attention towards encapsulation stability. Hence, we installed a biocompetable protein gatekeepers on the surface of drug loaded carriers. The GST-affibody possess important role in undergoing degradation in low pH. Further, this affibody can be conjugated with different types of antibody to target specific cancer cells to achieve a stable and biocompatible carrier for biomedical applications.
E-mail junyung0501@unist.ac.kr