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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-654 |
| Subject |
The novel anthraquinone derivative inducing death of human cancer cells |
| Authors |
Hyun Kyung Choi*, Bui Thi Hong Nhung1
Department of Medicinal Chemistry, Jungwon University, Korea
1Department of Medicinal Chemistry, Jungwon University, Korea
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| Abstract |
To identify novel small molecules that induce selective cancer cell death, we screened a chemical library containing 1040 compounds in HT29 colon cancer and CCD18-Co normal colon cells, using a phenotypic cell-based viability assay system with the Cell Counting Kit-8 (CCK-8).
We discovered a novel anthraquinone derivative, N-(4-[{(9,10-dioxo-9,10-dihydro-1-anthracenyl)sulfonyl}amino]phenyl)-Nmethylacetamide, which was cytotoxic against the human colon cancer cells tested. The novel anthraquinone derivative is a potent, cancer cell-specific cytotoxic agent. Furthermore, This derivative induced cell death through cell cycle arrest at the S and G2/M phases, and enhanced either the chemo or radiosensitivity of cancer cells. |
| E-mail |
hkchoi45@hanmail.net |
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121st General Meeting of the KCS