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| Type |
Poster Presentation |
| Area |
Organic Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
ORGN.P-545 |
| Subject |
Exploration of Phosphite Based Reductive Ligation of S-nitrosothiols |
| Authors |
Chung-Min Park
Chemistry, Gangneung-Wonju National University, Korea |
| Abstract |
S-Nitrosylation is a nitric oxide (NO)-mediated post-translational modification (PTM), which plays important regulatory roles in many biological systems. Although a large number of proteins have been suggested to be the targets of S-nitrosylation, the detection of S-nitrosylation is still a challenge. In the past several years bioorthogonal reactions of SNO with various phosphines have been aimed at developing new methods for detecting and labeling protein S-nitrosothiols. As it is known that azaylides as the key intermediates in these reactions can also be generated from phosphite substrates, we wondered if phosphites could be used to trap SNO. Here we present that the reaction with phosphites is selective for SNO (not for -SH, –S-S-, etc) like phosphine based ligations, but the products should be very different from the reactions with phosphine substrates. |
| E-mail |
parkc@gwnu.ac.kr |
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121st General Meeting of the KCS