Advanced glycation end-products (AGEs) are proteins or lipids that become glycated as a result of exposure of sugars. They can be a factor in aging and in the development or worsening of many degenerative diseases, such as diabetes, atherosclerosis, chronic renal failure, and Alzheimer’s diseases. Alagebrium (or ALT-711) and its analogs which have a 4,5-dimethylthiazolium moiety were known as AGE-breakers to break up some existing AGE crosslinks. In this work, we have synthesized new 4,5-dimethylthiazolium salts containing heterocyclic moieties as the AGE-breaker.