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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-655 |
| Subject |
Design and synthesis of TPH1 inhibitors for the obesity |
| Authors |
Eunjung Bae, HAUSHABHAU PAGIRE1, SUVARNA HAUSHABHAU PAGIRE1, JIN HEE AHN*
Department of Chemistry, Gwangju Institute of Science and Technology, Korea
1Department of Chemistry, Gwangju Institute of Science and Technology, India
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| Abstract |
Obesity is a global public health problem. The obesity epidemic has been growing in developed nations, including the United States, for decades. Moreover, this epidemic has spread to developing nations. The negative consequences of obesity have been quantified as exceeding those of either alcohol abuse or smoking. Serotonin (5-hydroxytryptophan) is a hormone that regulates emotions in the central system. In the peripheral system, it is a hormone related to induction of obesity. TPH1 (tryptophan hydroxylase 1) is a protein that synthesizes serotonin, thus TPH1 inhibitor could be a promising target for the treatment of obesity. In this meeting, discovery of TPH1 inhibitors will be presented. |
| E-mail |
helloimej@gist.ac.kr |
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121st General Meeting of the KCS