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| Type |
Poster Presentation |
| Area |
Analytical Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
ANAL.P-304 |
| Subject |
Separation of Racemic Omeprazole by Chiral Capillary Electrophoresis based on UV Detection |
| Authors |
GeonBok Lee, Minjeong Gu1, Seong Ho Kang*
Department of Applied Chemistry, Kyung Hee University, Korea
1Department of Chemistry, Kyung Hee University, Korea
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| Abstract |
Separation of (S), (R)-omeprazole which is a medication for the treatment of gastroesophageal reflux disease and peptic ulcer disease was performed on a lab-built capillary electrophoresis (CE) system coupled with a ultraviolet (UV) detector at 301 nm. In this study, 2-hydroxypropyl β-cyclodextrin (HP-β-CD) dissolved in 20 mM phosphate buffer (pH 6.0) was used as the chiral additive and the identification of omeprazole enantiomers dissolved in stock solution (CH3OH : NaOH = 9 : 1, v/v) was carried on the capillary with a total length of 40 cm and effective length of 25 cm based on capillary zone electrophoresis. Analysis times, shorter than 16 min were found using a background electrolyte solution consisting of 20 mM phosphate buffer conditioned to pH 6.0, 40 mM HP-β-CD, hydrodynamic injection (siphoning), and 15 kV separation voltage. |
| E-mail |
mangement@naver.com |
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121st General Meeting of the KCS