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| Type |
Symposium |
| Area |
Current Trends in Biological Chemistry |
| Room No. |
Room 203 |
| Time |
FRI 09:40-: |
| Code |
BIO3-3 |
| Subject |
Combination of viral gene delivery with smart fibrous matrices for gene and cell therapy applications |
| Authors |
JAE-HYUNG JANG
Chemical and Biomolecular Engineering, Yonsei University, Korea |
| Abstract |
Gene delivery has emerged as a powerful strategy for the treatment of a variety of human diseases, such as inherited or acquired genetic diseases, numerous cancers, and tissue loss/organ failures. A number of challenges associated with gene delivery – such as the spread of vectors to distant sites and inefficient delivery to some non-permissive cell types – have continuously emphasized the need for significant advancement in developing safe and efficient gene delivery systems. Electrospun nanofibers have been extensively explored as spatial templates that can retain cellular morphologies and deliver biomolecules efficiently toward target cell types. Encapsulation or immobilization of gene vectors within or onto electrospun nanofibers can enhance gene delivery through providing locally controlled release and maintaining its activity. Importantly, due to the ease of tuning structural variations of electrospun nanofibers, their capability to mediate controlled and sustained gene delivery has been recognized as the most representative feature of electrospun nanofibers compared to the other existing polymeric gene delivery templates. As a potential gene carrier candidate, the features of adeno-associated viral (AAV) vectors, which have been broadly used in many gene/cell therapy applications due to their safety and efficacy, will be primarily discussed. Several powerful tools to create de novo bio-inspired nanoparticles (i.e., AAV vectors) formulated with biomaterials for enhancing the capabilities of gene delivery will be introduced.
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| E-mail |
j-jang@yonsei.ac.kr |
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121st General Meeting of the KCS