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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-660 |
| Subject |
Synthesis and evaluation of gadolinium complex of oxopurine analogues for tumor targeted MRI contrast agents |
| Authors |
Ki-Hye JUNG, Kyo-Chul Lee, Yong Jin Lee, JUNG-YOUNG KIM, Ji Ae Park*
Division of RI-Convergence Research, Korea Institute of Radiological & Medical Science, Korea
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| Abstract |
Lung cancer remains the leading cause of cancer-related mortality worldwide. Non-small cell lung cancer (NSCLC), which does not show symptoms until an advanced tumor stage is reached, is difficult to diagnose and conventional screening methods often need to be repeated several times to determine localization, stage and aggressiveness of the tumor. Molecular imaging strategies have already shown immense clinical utility for the diagnosis of lung cancer; however, there is still a need for marker-specific tracers in this disease. Microtubule targeting agents (MTAs) constitute a class of drugs for cancer treatment. Microtubule play an irreplaceable role in a variety of cellular functions, including the maintenance of cell shape, polarity, vesicles, and mitosis. Oxopurine analogues was an MTA with good effects against NSCLC. Thus, we decided to develop a lung cancer specific imaging agent. In this study, we designed oxopurine analogue and evaluated its potential as MRI contrast agent for imaging NSCLC. |
| E-mail |
kihyessi@kirams.re.kr |
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121st General Meeting of the KCS