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| Type |
Poster Presentation |
| Area |
Medicinal Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-662 |
| Subject |
Synthesis and biological application of A2B corroles |
| Authors |
jihyun Baek, sungrae kim1, Ju Hwa Lee2, Yuyeong Jeon3, Yun ji Choi1, Yonghwang Ha*
Department of Medical Bioscience, Jungwon University, Korea
1Jungwon University, Korea
2Medicinal Chemistry, Jungwon University, Korea
3Department of Pharmaceutical Science, Jungwon University, Korea
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| Abstract |
During the tumor progression, it is hard to remove individual tumor cells by surgical operations because they are too small to remove via naked eyes. Many researches are interested in developing tumor-specific destruction method. As an alternative therapeutic skill, photodynamic therapy (PDT) attracts great interest due to its high selectivity. PDT is based on the photosensitizers which can generate singlet oxygen by energy transfer from triplet excited state sensitizer to molecular oxygen in ground state. Herein, we designed various types of A2B corroles as photosensitizers, synthesized, and characterized the photophysical properties via measuring of UV-vis absorbance, and emission spectra, etc. For the next step, we are planning to synthesize various halogenated metallocorroles and investigating phosphorescence properties and application for tumor removal potential in cellular level. |
| E-mail |
hyh3455@jwu.ac.kr |
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121st General Meeting of the KCS