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| Type |
Poster Presentation |
| Area |
Material Chemistry |
| Room No. |
Event Hall |
| Time |
4월 20일 (금요일) 11:00~12:30 |
| Code |
MAT.P-558 |
| Subject |
Water-soluble Quantum Dot Nanoprobes using multidentate ligangds for Point-of-Care Lateral Flow Assay |
| Authors |
Jinyeong Kim, oh seok kwon1,*
BNT research center, Korea Research Institute of Bioscience & Biotechnology, Korea
1BNT research center, KRIBB, Korea
|
| Abstract |
Lateral flow assays (LFA) are simple devices intended to detect the presence (or absence) of a target analyte in sample (matrix) without the need for specialized and costly equipment. Although, this diagnostic tools have provided attractive advantages, the limitations such as low sensitivity and storage remains as challenges. In this research, we provided quantum dots (QDs) based LFA with high sensitivity and long-term stability. Especially, QDs were synthesized under liquid state, so they have high stability and quantum yield. Moreover, the surface of the QDs was modified with multidentate ligands, such as carboxylic terminal groups and the HRP2 antibody were easily conjugated by EDC-NHS coupling reaction. The HRP2 antibody-conjugated QDs were used for LFA application and they showed higher detection level comparing to the conventional Au nanoparticle-based LFA kits. |
| E-mail |
nanggu88@naver.com |
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121st General Meeting of the KCS