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| Type |
Poster Presentation |
| Area |
Organic Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
ORGN.P-562 |
| Subject |
Synthesis of Chiral Cyclopentenone: Application to Total Synthesis of Prostanoids |
| Authors |
TAEHYEONG KIM, Do Hyun Ryu*
Department of Chemistry, Sungkyunkwan University, Korea
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| Abstract |
Cardiovascular diseases are the leading cause of mortality. These occupied a quarter of causes of death globally and have remained the biggest causes for past years. Animal secretes powerful vasodilator itself known as prostanoids. Because powerful actions of them in human body, synthetic salt is available as medicine. It is specifically used for direct vasodilation of pulmonary arterial vascular beds to treat pulmonary arterial hypertention.
PGF2α and PGI2 metabolite are chosen as the target molecules. For synthesizing them, we anticipated that chiral cyclopentenone could be the key intermediate for construction of all requisite stereocenters on cyclopentane backbone through 3 component coupling.
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| E-mail |
dlfhtkzl@naver.com |
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121st General Meeting of the KCS