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|
| Type |
Poster Presentation |
| Area |
Organic Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
ORGN.P-563 |
| Subject |
Enantioselective total synthesis of cytotoxic chiral natural products from Cinnamomum subavenium via MBH ester |
| Authors |
Dong Guk Nam, Do Hyun Ryu*
Department of Chemistry, Sungkyunkwan University, Korea
|
| Abstract |
Secobuatnolide and subamolide series has been reported as biological activities. These structures exhibit strong cytotoxicity against human cancer cells such as Hep G2 cell line and p-388 cell line. And total synthesis of these molecule haven’t reported. An enantioselective synthesis of β-iodo Morita-Baylis-Hillman ester has been developed three-component coupling reaction with oxazaborolidinium catalyst (COBI). Iodine catalyzed isomerization produces a geometric isomer in good yield. Total synthesis of secobutanolide series has been accomplished after organocuprate and ozonolysis. |
| E-mail |
skaekhd@gmail.com |
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121st General Meeting of the KCS