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| Type |
Poster Presentation |
| Area |
Organic Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
ORGN.P-572 |
| Subject |
Triethylborane-mediated radical addition reaction : synthesis of quaternary α-alkyl substituted amino acid "on water"
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| Authors |
TAE KYU NAM, Doo OK JANG*
Department of Chemistry, Yonsei University, Korea
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| Abstract |
Water is an interesting solvent in organic synthesis, because it has good abilities not only physical and chemical properties but also economic and environmental aspects. Various advantages such as acceleration of reaction rate and increasing selectivity of specific product using water have been reported. Despite of these advantages, water is still not frequently used in organic reactions, because of its unique characteristics like low solubility of organic compounds in water and the possibility of hydrolyzing the reactants. In radical process, solvent effects of water are known to insignificant.
Herein, we wish to report radical addition reactions to hydrazone derived from α-keto ester using triethylborane as a radical initiator on water affording biologically active quaternary α-substituted amino acid derivatives. In the course of the reaction, a significant solvent effect was observed.
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| E-mail |
tang2angel@naver.com |
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121st General Meeting of the KCS