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| Type |
Poster Presentation |
| Area |
Organic Chemistry |
| Room No. |
Event Hall |
| Time |
4월 19일 (목요일) 11:00~12:30 |
| Code |
ORGN.P-574 |
| Subject |
Improved Maltose Neopentyl Glycol Amphiphiles for Membrane Protein Stability |
| Authors |
HYOUNG EUN BAE, Pil Seok Chae*
Department of Bionano Engineering, Hanyang University, Korea
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| Abstract |
Detergents are widely used in membrane protein research, particularly for membrane protein structural studies. However, many membrane proteins tend to aggregate or denature with time when solubilized in a conventional detergent, necessitating the development of new agents with distinct architecture and enhanced efficacy. Over the past few years, a maltose neopentyl glycol (MNG) amphiphile, known as lauryl maltose neopentyl glycol (LMNG), has facilitated crystal structure determinations of approximately 30 membrane proteins including various GPCRs. This noel agent contains two alkyl chains with the same chain length. In this presentation, we introduce LMNG variants with different alkyl chain length. This structural modification results in length variation in the hydrophobic groups and molecular geometry of detergent molecules, thus affecting detergent efficacy for membrane protein solubilization and stabilization. |
| E-mail |
hyoungeun@hanyang.ac.kr |
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121st General Meeting of the KCS