KCS 121st General Meeting

Subject Highly selective detection of spermine based on the fluorescence quenching of heparin using CdTe quantum dots coated with amphiphilic thiophene copolymers
Code ANAL2.O-14
Time FRI 10 : 13
Area Oral Presentation of Young Analytical Chemists II
Type Oral Presentation
Authors Jimin Shim, Salah Mahmoud Tawfik Ahmed, YONG-ILL LEE*
Department of Chemistry, Changwon National University, Korea
Abstract Novel optical sensors based on CdTe quantum dots (P1QDs and P2QDs) coated with amphiphilic thiophene copolymers were developed for the detection of spermine. The emission of the P1QDs and P2QDs is found to be quenched in the presence of heparin by electron transfer mechanism through electrostatic and hydrogen bonding interactions. Upon the addition of spermine, heparin has been removed from the surface of P1QDs and P2QDs due to the strong electrostatic interactions between spermine and heparin, which showed significant fluorescence recovery of the sensors. Under optimum conditions, both P1QDs and P2QDs sensors displayed excellent analytical performance for spermine with the limit of detection (LOD) of 2.90 nmol L-1 and good linearity (R2= 0.9957) within 0.05-15 μmol L-1 and LOD of 1.66 nmol L-1 and good linearity (R2 = 0.9928) within 1-12 μmol L-1, respectively. The P1QDs and P2QDs sensors show a high selectivity to spermine over common interfering substances. Furthermore, the proposed method was successfully utilized in serum samples with satisfactory results. Keywords: amphiphilic copolymers; QDs; spermine; optical sensors; serum samples; electron transfer
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