A convenient, environmentally friendly and efficient procedure for the synthesis of novel 3-amino-2-benzoyl-1-aryl-1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives have been developed by one-pot three-component condensation reaction of phthalhydrazide, aldehydes and benzoylacetonitrile in the presence of catalytic amount of p-toluenesulfonic acid (p-TSA) as a acid catalyst in EtOH at 80 °C conditions. This new protocol offers an environmental acceptability, shorter reaction time, low cost, high yields, a wide range of functional group tolerance, simple and easy experimental work-up procedure.