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Type |
Poster Presentation |
Area |
Organic Chemistry |
Room No. |
Grand Ballroom |
Time |
10월 18일 (목요일) 11:00~12:30 |
Code |
ORGN.P-53 |
Subject |
Synthesis of Multisubstituted Allenes, Furans, and Pyrroles via Palladium-Catalyzed Substitution and Cycloisomerization in one pot |
Authors |
Dae Kyum Kim, Sang Hoon Han, Jinhui Won, Phil Ho Lee* Department of Chemistry, Kangwon National University, Korea |
Abstract |
Recently, an efficient synthetic method towards multisubstituted furans and pyrroles bearing hetero-substituents was reported through metal-catalyzed 1,2-shifts of diverse migrating groups in allenyl systems. However, the introduction of a wide variety of substituents at the 4-position of furans and pyrroles is impossible due to requirement of [1,3]-H shift in these methods. Therefore, the development of an efficient synthetic method for multisubstituted furans and pyrroles bearing 3-heteroatom substituents as well as substituents at the 4-position has been a continuing challenge.
Herein, we report Pd-catalyzed propargyl substitution reactions of propargyl acetates with indium organothiolates for the synthesis of multisubstituted allenyl sulfides. This procedure employed tandem Pd-catalyzed propargyl substitution and cycloisomerization reactions from indium organothiolates and propargyl acetates bearing acyl and imidoyl groups for the synthesis of multisubstituted furans and pyrroles in one-pot.
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E-mail |
kimdk0421@nate.com |
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