|
|
| Type |
Poster Presentation |
| Area |
Inorganic Chemistry |
| Room No. |
Grand Ballroom |
| Time |
10월 19일 (금요일) 11:00~12:30 |
| Code |
INOR.P-36 |
| Subject |
Minor Structural Variations of Small Molecules Tune Regulatory Activities toward Pathological Factors in Alzheimer’s Disease |
| Authors |
Mingeun Kim, Mi Hee Lim1,*
Department of Chemistry, Ulsan National Institute of Science and Technology, Korea
1Department of Chemistry, Korea Advanced Institute of Science and Technology, Korea
|
| Abstract |
Chemical tools have been valuable for establishing a better understanding of the relationships between metal ion dyshomeostasis, the abnormal aggregation and accumulation of amyloid-β (Aβ), and oxidative stress in Alzheimer’s disease (AD). Still, very little information is available to correlate the structures of chemical tools with specific reactivities used to uncover such relationships. Recently, slight structural variations to the framework of a chemical tool were found to drastically determine the tool’s reactivities toward multiple pathological facets to various extents. In this presentation, we will present our rational design and characterization of a structural series to illustrate the extent to which the reactivities of small molecules vary toward different targets as a result of minor structural modifications. These compounds were rationally and systematically modified based on consideration of properties, including ionization potentials and metal binding, to afford their desired reactivities with pathological factors in AD. Together, our studies demonstrate the rational structure-directed design that can be used to develop chemical tools capable of regulating individual or interrelated pathological features in AD. |
| E-mail |
mingeun0118@gmail.com |
|
122nd General Meeting of the KCS