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| Type |
Poster Presentation |
| Area |
Life Chemistry |
| Room No. |
Grand Ballroom |
| Time |
10월 19일 (금요일) 11:00~12:30 |
| Code |
LIFE.P-412 |
| Subject |
A Near-Infrared Fluorescent Probe for Amyloid-β Aggregates |
| Authors |
Misun Lee, Mingeun Kim1, Tikum Florence Anjong2, Hyuck Jin Lee, Mi Hee Lim3,*, Jinheung Kim2,*
Ulsan National Institute of Science and Technology, Korea
1Chemistry, Ulsan National Institute of Science and Technology, Korea
2Department of Chemistry and Nano Science, Ewha Womans University, Korea
3Department of Chemistry, Korea Advanced Institute of Science and Technology, Korea
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| Abstract |
The deposition of amyloid-β (Aβ) aggregates in the brain is a hallmark of Alzheimer’s disease (AD)-affected brain. The toxicity associated with Aβ aggregation and generated Aβ aggregates has been gained much attention to elucidate the pathogenesis of AD. To elucidate a relationship between Aβ species and toxicity, an effective strategy, such as utilization of a fluorescence probe, to noninvasively identify the existence of Aβ peptides in biological environments is necessary. In this presentation, we will report a new, turn-on near-infrared fluorescent dimethyaminostyrene- and indole-based probe, 1, for Aβ aggregates, which consists of a donor-π conjugation-acceptor structure with an Aβ-interacting moiety. Our probe, 1, shows a noticeable increase in fluorescence at ca. 710 nm upon treatment of Aβ aggregates in aqueous media. Moreover, 1 is observed to be nontoxic under imaging conditions and detect Aβ species in living cells.
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| E-mail |
lmsun0211@unist.ac.kr |
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122nd General Meeting of the KCS