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|
| Type |
Poster Presentation |
| Area |
Polymer Chemistry |
| Room No. |
Grand Ballroom |
| Time |
10월 18일 (목요일) 11:00~12:30 |
| Code |
POLY.P-3 |
| Subject |
Reactive oxygen species and thiol responsive micelles for efficient delivery of anti-cancer therapeutics |
| Authors |
Young In Choi, Hyun-Chul Kim*
Magnet-Controlled Materials Research Group, Daegu Gyeongbuk Institute of Science & Technology, Korea
|
| Abstract |
Gemini amphiphile consisting of hydrophilic poly(ethylene glycol) (PEG) and hydrophobic poly(methionine) (PMT) with cystine disulfide spacers was synthesized and its micellar properties for thiol- or ROS (reactive oxygen species)-dependent intracellular drug delivery are described. The cleavage of cystine linkage in redox environment or the oxidation of methionine units in ROS environment caused the destabilization of micelles. Such redox- or ROS-triggered micellar destabilization led to enhanced release of encapsulated DOX (doxorubicin) to induce cytotoxicity against cancer cells. Therapeutic effects of the DOX-loaded micelles are demonstrated using KB cell line. This study shows that thiol and ROS dual responsive gemini micelles have potential use as a promising platforms for nano-drug delivery in various cancer therapies.
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| E-mail |
cyi9161@dgist.ac.kr |
122nd General Meeting of the KCS