122nd General Meeting of the KCS

Type Award Lecture in Division
Area Recent Researches of Inorganic Chemists
Room No. Room 323
Time THU 09:20-:
Code INOR.O-2
Subject Molecular Biomimetics for Drug Development & Energy Conversion
Authors Jaeheung Cho
Emerging Materials Science, DGIST, Korea
Abstract Enzymes, responsible for thousands of metabolic processes that sustain life, are macromolecular biological catalysts. Molecular biomimetics is an emerging area where hybrid technologies are developed by using the tools of synthetic chemistry, molecular biology and nanotechnology. In this talk, we will present our recent results on the molecular biomimetics for metal-reactive oxygen species mimicking the active site of O2 activating enzymes. The metal ions and the supporting ligands are found to be important factors that control the geometric and electronic structures of the metal-reactive oxygen species. Reactivity studies performed with the metal-reactive oxygen species toward external substrates provide mechanistic insight into the active site of metalloenzymes for small molecule activation and/or inhibition. Finally, we are going to introduce our ongoing research at DGIST on molecular biomimetics for medicinal applications and small molecule activation related on the energy conversion.
E-mail jaeheung@dgist.ac.kr