|
Type |
Poster Presentation |
Area |
Physical Chemistry |
Room No. |
Grand Ballroom |
Time |
10월 19일 (금요일) 11:00~12:30 |
Code |
PHYS.P-192 |
Subject |
Interactions of naphthol-based photoacids with bovine and human serum albumins investigated by the excited-state proton transfer reaction |
Authors |
Seong-June Lee, Han Gook Cho*, Byeong-Seo Cheong* Department of Chemistry, Incheon National University, Korea |
Abstract |
The interactions of several different naphthol-based photoacids with bovine and human serum albumins have been investigated by observing the excited-state proton transfer (ESPT) of photoacids. Two bands due to the protonated and deprotonated forms of the photoacid were observed in the fluorescence emission spectra, and the fluorescence intensity ratios of the two bands were monitored as the concentration of bovine or human serum albumin in phosphate buffer was varied. It was found that the variation of the fluorescence intensity ratios of the two forms, and thus the degree of the ESPT process, was significantly different depending on the position of the hydroxyl and sulfonate groups of the photoacid as well as the type of serum albumin. The possible binding interaction and configuration of the photoacid in the binding site of serum albumin were discussed. |
E-mail |
leesjch@naver.com |
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