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Type |
Poster Presentation |
Area |
Organic Chemistry |
Room No. |
Grand Ballroom |
Time |
10월 18일 (목요일) 11:00~12:30 |
Code |
ORGN.P-67 |
Subject |
Generation and Application of (Diborylmethyl)zinc(II) Species: Access to Enantioenriched gem-Diborylalkanes by an Asymmetric Allylic Substitution |
Authors |
Yeosan Lee, Jinyoung Park, Seung Hwan Cho* Department of Chemistry, Pohang University of Science and Technology, Korea |
Abstract |
We report the successful generation of (diborylmethyl)zinc(II) species by transmetallation between isolable (diborylmethyl)lithium and zinc(II) halide (X = Br, Cl) and their application in the synthesis of enantioenriched gem-diborylalkanes bearing a stereogenic center at the β-position of the diboryl groups by an asymmetric allylic substitution reaction. The reaction has a broad substrate scope, and various enantioenriched gem-diborylalkanes can be obtained in good yields with excellent enantioselectivity. Further elaboration of the enantioenriched gem-diborylalkanes provides access to a diverse set of valuable chiral building blocks. |
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E-mail |
yeosan0722@postech.ac.kr |
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