In the previous study, we synthesized and studied various oligomers using cyclic β-amino acids such as amino cyclopentane carboxylic acid (ACPC) and amino cyclohexane carboxylic acid (ACHC). In particular, trans compounds form beta sheets, showing that they form 10/12 or 12/10 helix structures using cis compound.
In this study, we tried to implement helical structures of nylon-like oligomers, which were synthesized using 1,2-diamine and 1,2-dicarboxylic acid.
However, synthesized oligomers with acyclic residues were not robust, so cyclic residues were incorporated into oligomers, because we expected that helical propensity of the oligomers is enhanced. In addition, cyclic residues may increase the solubility in organic solvents.
For the above reasons, the oligomers were synthesized using acetoneide and cylopentane diamine. And we analysized synthesized compounds through CD, IR, and 2D NMR.
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