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|
| Type |
Poster Presentation |
| Area |
Life Chemistry |
| Room No. |
Grand Ballroom |
| Time |
10월 19일 (금요일) 11:00~12:30 |
| Code |
LIFE.P-414 |
| Subject |
Nucleotide hydrolysis and nucleic acid unwinding analysis of Middle East Respiratory Syndrome coronavirus helicase |
| Authors |
Yong-Joo Jeong
Department of Applied Chemistry, Kookmin University, Korea |
| Abstract |
An infectious respiratory disease, Middle East Respiratory Syndrome (MERS), is caused by a modified coronavirus. MERS coronavirus is a (+) single stranded RNA virus. Of the several non-structural proteins produced from the virus, NTPase/helicase plays an important role in viral replication. Helicases are molecular motors that separate double-stranded nucleic acids using the energy generated by NTP hydrolysis. In the present study, we analyzed the NTP hydrolysis and nucleic acid unwinding activities of MERS helicase. Based on the results, we developed an efficient high-throughput screening system to find inhibitory molecules. |
| E-mail |
jeongyj@kookmin.ac.kr |
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122nd General Meeting of the KCS