122nd General Meeting of the KCS

Type Poster Presentation
Area Organic Chemistry
Room No. Grand Ballroom
Time 10월 18일 (목요일) 11:00~12:30
Code ORGN.P-72
Subject Practical and Efficient Strategy for Synthesis of Aromatic Abietane Diterpenoids from Geraniol
Authors Young Seok Kim, Taejung Kim1, Sinae Lee2, Joonseong Hur1, Euna Ko3, WonJo Jeong, Yurngdong Jahng4,*, Jae Gyu Park5,*, Jungyeob Ham1,*
Gangneung-Wonju National University, Korea
1Natural Products Research, Korea Institute of Science and Technology, Korea
2Department of Chemistry, Korea Institute of Science and Technology, Korea
3Chemistry, Gangneung-Wonju National University, Korea
4Yeungnam University, Korea
5# Advanced Bio Convergence Center (ABCC), Pohang TechnoPark Foundation, Korea
Abstract Aromatic abietane diterpenoids are naturally occurring phenolic tricyclic compounds that have a wide range of biological properties, including antitumor, antimicrobial, antiviral, antiulcer, antileishmanial, antiplasmodial, antifungal, cardiovascular, antioxidant, antibacterial as well as anti-inflammatory activity. Among these compounds, C-12 (and C-7) oxidized aromatic abietane compounds: ferruginol, sugiol, and sugiol methyl ether isolated from Podocarpus ferrugineus, Juniperus communis L., and Melia azadirachta Linn., respectively, have been most widely investigated in the field of natural products synthesis and biological studies. In addition, increased biological activities of these synthetic derivatives possessing an aromatic C-ring have been reported. Thus, the unique and simple structure of aromatic abietane diterpenoids can be used as a template for lead compounds in the development of new drugs that are derived from natural products. Although several methods have been developed for the synthesis of aromatic abietane diterpenoids, some have disadvantages including multiple steps, tedious separation, and expensive starting materials. Herein, we report a practical and efficient strategy for the synthesis of three aromatic abietane diterpenoids from a simple starting material: geraniol. In this poster, detailed synthetic routes will be described.
E-mail kgsing@gmail.com