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|
| Type |
Poster Presentation |
| Area |
Analytical Chemistry |
| Room No. |
Grand Ballroom |
| Time |
10월 19일 (금요일) 11:00~12:30 |
| Code |
ANAL.P-341 |
| Subject |
NMR-based urinary profiling reveals different metabolic patterns in focal segmental glomerulosclerosis and minimal-change disease |
| Authors |
Jin Seong Hyeon, Geum-Sook Hwang*
Korea Basic Science Institute, Korea
|
| Abstract |
Focal segmental glomerulosclerosis (FSGS) and a related disorder, minimal-change disease (MCD), are idiopathic glomerular disease related to podocytopathies. Although the renal biopsy is mandatory to confirm the diagnosis and guide therapeutic plans in patients with FSGS and MCD, biopsy is an invasive procedure affected by complications. We performed NMR-based urinary metabolic profiling analysis to investigate metabolic differences between FSGS and MCD. The PCA scatter plot showed a clear separation between FSGS and control groups. Moreover, MCD groups were slightly separated from FSGS groups. The significant metabolic alteration in FSGS and MCD groups compared to healthy control groups were related to tricarboxylic acid cycle, choline, and branched chain amino acid metabolism. Furthermore, metabolite that are significantly altered in the FSGS groups included alanine and lactate, whereas MCD groups contained 3-aminoisobutyrate. This study demonstrates that metabolic profiling is useful for understanding metabolic differences between FSGS and MCD patients, and diagnosing kidney disease. |
| E-mail |
blackstar16@naver.com |
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122nd General Meeting of the KCS