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|
| Type |
Poster Presentation |
| Area |
Physical Chemistry |
| Room No. |
Grand Ballroom |
| Time |
10월 19일 (금요일) 11:00~12:30 |
| Code |
PHYS.P-210 |
| Subject |
Ultrasmall Gadolinium Oxides Nanoparticles Coated Poly(Acrylic Acid)-RGD as Theragnostic Agent: MRI and Gadolinium Neutron Capture Therapy |
| Authors |
Son-Long Ho, Gang Ho Lee*
Department of Chemistry, Kyungpook National University, Korea
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| Abstract |
Theragnostic agents are compounds that able for both diagnosis and therapy of diseases, which provide more advantages than a single-modal agent. In this work, ultrasmall gadolinium oxides nanoparticles which were coated with poly(acrylic acid) and linear RGD showed excellent magnetic resonance imaging properties and cancer-targetting ability, due to the presence of RGD moiety. Furthermore, these Gd2O3 NPs are also applied for gadolinium neutron capture therapy (GdNCT) on human glioblastoma U87MG cells and showed good results both in vitro and in vivo.
Herein, poly(acrylic acid)-RDG coated gadolinium oxide nanoparticles were synthesized and used as MRI and in vivo gadolinium neutron capture therapy agent (GdNCT) of human glioblastoma astrocytoma (U87MG) cells.
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| E-mail |
sonlongh@gmail.com |
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122nd General Meeting of the KCS