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| Type |
Poster Presentation |
| Area |
Physical Chemistry |
| Room No. |
Grand Ballroom |
| Time |
10월 19일 (금요일) 11:00~12:30 |
| Code |
PHYS.P-212 |
| Subject |
Synthesis and Characterization of PAA@Gd2O3 NPs as Multi-Purpose Therapeutic Agent |
| Authors |
Yeong Ji Jang, Gang Ho Lee1,*
Kyungpook National University, Korea
1Department of Chemistry, Kyungpook National University, Korea
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| Abstract |
Magnetic resonance imaging (MRI) has played a vital role in clinical diagnosis because of its high spatial resolution and great sensitivity. Besides, MRI can be used with remedial agent which is able for both diagnosis and therapy of disease. In this regard, gadolinium nanoparticles have great potential to act as therapeutic contrast agents. First of all, gadolinium ion (Gd(III)) has seven unpaired 4f electrons (8S7/2), which generate large electron magnetic moment, also, Gd(III) efficiently induces the longitudinal relaxation of water protons. That makes Gd(III) the most suitable T1 MRI contrast agent. Second, Gadolinium has high thermal neutron capture cross-section (), for example 157Gd isotope has S-value of 254000 barnes, that is 60 times larger than the value of 10B, a commercialized agent for boron neutron capture therapy (BNCT). Therefore, gadolinium nanoparticles are preferable agent for neutron capture therapy of tumors. In this study, Gadolinium oxide nanoparticles coated with polyacrylic acid (PAA) -rhodamine B (Rho) were synthesized and used as MRI, tumor detection agent and in vitro gadolinium neutron capture therapy agent (GdNCT) of human glioblastoma astrocytoma (U87MG) cells. |
| E-mail |
yjijg@hanmail.net |
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122nd General Meeting of the KCS