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|
| Type |
Poster Presentation |
| Area |
Physical Chemistry |
| Room No. |
Grand Ballroom |
| Time |
10월 19일 (금요일) 11:00~12:30 |
| Code |
PHYS.P-214 |
| Subject |
Synthesis, characterization, and enhanced cancer-imaging of TAT-peptide conjugated ultrasmall Gd2O3 nanoparticles |
| Authors |
Mohammad Yaseen Ahmad, Gang Ho Lee1,*
Kyungpook National University, India
1Department of Chemistry, Kyungpook National University, Korea
|
| Abstract |
Trans-activator of transcription (TAT) peptide conjugated ultrasmall gadolinium oxide (Gd2O3) nanoparticles were synthesized using a one-pot process. The obtained nanoparticles were characterized by FT-IR, XRD and TEM. The average particle diameter of the GNPs was 1.5 nm. The cytotoxicity of the TAT peptide-GNPs was studied with cancer cell lines DU145 and NCTC1469. We measured in vivo T1 magnetic resonance (MR) images in a model nude mouse with liver cancer before and after to intravenous administration. The sample solution exhibited a longitudinal water proton relaxivity (r1) of 18.2 s-1mM-1 (r2/r1 = 1.6, r2 = transverse water proton relaxivity), which is 4 - 5 times higher than those of commercial Gd-chelates. This demonstrates the feasibility of using functionalized ultrasmall gadolinium oxide nanoparticles with uniform (~1.5 nm) sizes as an enhanced cancer-imaging agent similar to the cancer-targeting agent in T1 MR imaging (T1 MRI). |
| E-mail |
yaseen.knu@gmail.com |
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122nd General Meeting of the KCS