122nd General Meeting of the KCS

Type Poster Presentation
Area Material Chemistry
Room No. Grand Ballroom
Time 10월 18일 (목요일) 11:00~12:30
Code MAT.P-353
Subject Antiplatelet coating with poly((3-methacryloylamino)propyl-dimethyl(3-sulfopropyl)ammonium hydroxide) on titanium dioxide and stainless steel
Authors JiHwan Eom, Yeonwoo Jeong1, Sung Min Kang2, Woo Kyung Cho*
Department of Chemistry, Chungnam National University, Korea
1Department of Chemistry, Chungbuk Natioanl University, Korea
2Department of Chemistry, Chungbuk National University, Korea
Abstract When medical devices such as stent and catheter are inserted in blood vessel, platelet adhesion can cause a serious problem like blood coagulation, resulting in vascular clogging. To inhibit platelet adhesion on medical devices, in this work, we employed a zwitterionic material, (3-methacryloylamino)propyl)-dimethyl(3-sulfopropyl)ammonium hydroxide) (MPDSAH) by considering that zwitterionic polymers have antifouling effects by strongly stabilizing the hydration layer formed by aqueous solution. Titanium dioxide (TiO2) and stainless steel (SS), which are mainly used in medical devices, were chemically modified by surface-initiated atom transfer radical polymerization of MPDSAH. The surface-grafted polymeric films were characterized with ellipsometer, contact angle goniometer, X-ray photoelectron spectroscopy, and atomic force microscopy. Compared with bare substrates, the poly(MPDSAH)-coated substrates effectively reduced both fibrinogen and platelet adhesions. The platelet adhesion was reduced by 86% and 92% for the polymer-coated TiO2 and SS substrates, respectively.
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