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| Type |
Oral Presentation |
| Area |
Oral Presentation of Young Biological Chemists |
| Room No. |
Room 314 |
| Time |
THU 09:20-: |
| Code |
LIFE.O-2 |
| Subject |
Plausible way for abiotic production of ribonucleosides |
| Authors |
Inho Nam
Chemistry and Bio-Environmental Sciences, Seoul Women's University, Korea |
| Abstract |
The feasibility of the abiotic fabrication of ribonucleosides which are the building blocks of ribonucleic acid (RNA) has been questionable because a condensation reaction between ribose and nucleobases is thermodynamically unfavorable in bulk environment. Here, I describe an abiotic synthetic path for ribonucleosides, both purine and pyrimidine ribonucleosides in water microdroplets, following a salvage reaction pathway in cells. The abiotic reaction path includes a condensation reaction between ribose and phosphate to give ribose 1-phosphate and an exchange reaction between nucleobase and phosphate in the ribose 1-phosphate. The reaction steps were forced by water microdroplets that changes the thermodynamic property of condensation reaction and accelerated by divalent magnesium ion, Mg2+, as a catalyst. In the bulk environment, the condensation reaction for giving ribose 1-phosphate has the positive value of Gibb’s free energy change (ΔG). However, ΔG changes to the negative value in microdroplets, which makes the abiotic salvage pathway spontaneous. Consequently, both types of ribonucleosides, purine and pyrimidine ribonucleosides, could have arisen through the same chemical environment, which means that simultaneous production of random ribonucleosides might be possible for generating chains of RNA in microdroplets. |
| E-mail |
inhonam@swu.ac.kr |
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122nd General Meeting of the KCS